Threshold Pharmaceuticals, Inc. (Nasdaq: THLD) 8.9% HIGHER; announced preclinical results related to Threshold's clinical stage hypoxia-activated prodrug, TH-302.
The study found that almost all of the MM cells in the model reside in a hypoxic environment in the bone marrow and that these tumor cells may be a target for tumor-specific treatment with TH-302.
In vivo, animals treated prophylactically with TH-302 showed decreased serum paraprotein compared to those not treated with TH-302.
The frequency of apoptotic MM cells in bone...
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